Optimal acquisition schemes for in vivo quantitative magnetization transfer MRI

6772 In - vivo Magnetization Transfer

In-vivo Magnetization Transfer Imaging of Mouse Lungs using a Zero Echo Time Sequence at 4.7 T – initial Experience. Moritz C Wurnig, Mingming Wu, Wolfgang Jungraithmayr, Markus Weiger, Klaas P Pruessmann, and Andreas Boss Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Zurich, Switzerland, Institute for Biomedical Engineering, University and Swiss Fede...

Pathological Assessment of Brain White Matter in Relapsing-Remitting MS Patients using Quantitative Magnetization Transfer Imaging

Introduction: Multiple sclerosis (MS) is characterized by lesions in the white matter (WM) of the central nervous system. Magnetic resonance imaging is the most specific and sensitive method for diagnosis of multiple sclerosis. However, the ability of conventional MRI to show histopathologic heterogeneity of MS lesions is insufficient. Quantitative magnetization transfer imaging (qMTI) is a rel...

An optimized framework for quantitative magnetization transfer imaging of the cervical spinal cord in vivo

PURPOSE To develop a framework to fully characterize quantitative magnetization transfer indices in the human cervical cord in vivo within a clinically feasible time. METHODS A dedicated spinal cord imaging protocol for quantitative magnetization transfer was developed using a reduced field-of-view approach with echo planar imaging (EPI) readout. Sequence parameters were optimized based in th...

Quantitative Magnetization Transfer Imaging Techniques and Applications

Myelin breakdown in human Huntington’s disease: Multi-modal evidence from diffusion MRI and quantitative magnetization transfer

Huntington's disease (HD) leads to white matter (WM) degeneration that may be due to an early breakdown in axon myelination but in vivo imaging correlates of demyelination remain relatively unexplored in HD compared to other neurodegenerative diseases. This study investigated HD-related effects on a putative marker of myelin, the macromolecular proton fraction (MMPF) from quantitative magnetiza...